LANOXIN PEDIATRIC

LOE Approaching

digoxin

NDAINJECTIONINJECTABLEPriority Review
Approved
Nov 1954
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20

Mechanism of Action

digoxin's actions are mediated through its effects on Na-K ATPase. This enzyme, the "sodium pump," is responsible for maintaining the intracellular milieu throughout the body by moving sodium ions out of and potassium ions into cells. By inhibiting Na-K ATPase, digoxin causes increased availability…

Pharmacologic Class:

Cardiac Glycoside

Clinical Trials (5)

NCT07215260Phase 1Completed

A Study in Healthy People to Test Whether BI 3000202 Affects How 2 Other Medicines (Rosuvastatin and Digoxin) Are Taken up in the Body

Started Nov 2025
14 enrolled
Healthy
NCT06921941Phase 1Completed

Drug-drug Interaction Study of Bemnifosbuvir/Ruzasvir (BEM/RZR) and Digoxin and Rosuvastatin

Started Apr 2025
38 enrolled
Healthy Volunteer Study
NCT06597760Phase 1Completed

A Clinical Study to Assess the Effect of Enlicitide on How the Body Processes Digoxin in Healthy Adult Participants (MK-0616-031)

Started Oct 2024
24 enrolled
Healthy
NCT06575933Phase 1Completed

A Study of Calderasib (MK-1084) With Midazolam and Digoxin in Healthy Participants (MK-1084-009)

Started Sep 2024
28 enrolled
Non-small Cell Lung Cancer
NCT06503679Phase 1Completed

A Drug-drug Interaction Study Evaluating the Perpetrator Potential of LY4100511 (DC-853) on Midazolam, Repaglinide, Digoxin, Rosuvastatin in Healthy Participants

Started Jul 2024
49 enrolled
Healthy