NDAORALTABLET
Approved
Sep 1997
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
LANOXIN (digoxin) by Pfizer is digoxin's actions are mediated through its effects on na-k atpase. First approved in 1997.
Drug data last refreshed 6h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LANOXIN (digoxin) is a cardiac glycoside oral tablet approved in 1997 that increases myocardial contractility and slows heart rate by inhibiting Na-K ATPase and enhancing parasympathetic tone. It is used in heart failure and atrial fibrillation to improve cardiac output and control ventricular rate. The drug works through complex mechanisms including increased intracellular calcium, reduced AV node conduction velocity, and neurohormonal deactivation.
LOE Approaching
Product is nearing loss of exclusivity with moderate competitive pressure (30/100), signaling reduced team investment and transition planning.
Mechanism of Action
digoxin's actions are mediated through its effects on Na-K ATPase. This enzyme, the "sodium pump," is responsible for maintaining the intracellular milieu throughout the body by moving sodium ions out of and potassium ions into cells. By inhibiting Na-K ATPase, digoxin causes increased availability…
Pharmacologic Class:
Cardiac Glycoside
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.