LAMOTRIGINE

Post-LOE

lamotrigine extended-release

ANDAORALTABLET, EXTENDED RELEASE
Approved
Dec 2021
Lifecycle
Post-LOE
Competitive Pressure
30/100
Clinical Trials
20

Mechanism of Action

Organic Cation Transporter 2 Inhibitors

Pharmacologic Class:

Anti-epileptic Agent

Clinical Trials (5)

NCT07140913Phase 3Recruiting

A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine

Started Oct 2025
424 enrolled
ManiaBipolar Disorder
NCT06729970Phase 1Completed

A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy Participants

Started Dec 2024
NCT04602221Phase 1Completed

A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine

Started Dec 2020
40 enrolled
Healthy
NCT04156035N/ACompleted

Ketamine-Induced Brain Changes and Their Modulation by Lamotrigine

Started Mar 2020
75 enrolled
Emotions
NCT02513654Phase 1Completed

Pharmacokinetics, Safety and Tolerability of Repeat Dosing Lamotrigine in Healthy Chinese Subjects

Started Sep 2015
16 enrolled
Bipolar Disorder