KYPROLIS

Peak

carfilzomib

NDAINTRAVENOUSPOWDER
Approved
Jul 2012
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
20

Mechanism of Action

Proteasome Inhibitors

Pharmacologic Class:

Proteasome Inhibitor

Clinical Trials (5)

NCT07479979Phase 1/2Not Yet Recruiting

Study of Selinexor With Carfilzomib, Isatuximab and Dexamethasone for Patients With Relapsed and/or Refractory Multiple Myeloma

Started Jul 2026
62 enrolled
Relapse Multiple MyelomaRefractory Multiple Myeloma
NCT07348393Phase 2Not Yet Recruiting

A Phase 2, Single Arm Multicenter, Study Testing Mezigdomide, Carfilzomib, and Dexamethasone (480Kd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Started Feb 2026
70 enrolled
Relapsed or Refractory Multiple Myeloma (RRMM)
NCT07222761Phase 3Recruiting

A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy With Standard-of-Care Combination Regimens in Adult Participants With Relapsed/Refractory Multiple Myeloma (RRMM)

Started Jan 2026
915 enrolled
Relapsed and/or Refractory Multiple Myeloma (RRMM)
NCT06892522Phase 1/2Recruiting

A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion Alone or in Combination With Oral, IV, Subcutaneous Daratumumab; Lenalidomide; Dexamethasone; Carfilzomib

Started Jun 2025
440 enrolled
Multiple Myeloma
NCT06356571Phase 2Recruiting

A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma

Started Mar 2025
64 enrolled
Plasma Cell Myeloma Refractory

Loss of Exclusivity

LOE Date
Aug 27, 2033
91 months away
Patent Expiry
Aug 27, 2033
Exclusivity Expiry
Nov 22, 2028

Patent Records (5)

Patent #ExpiryTypeUse Code
7417042
Jul 20, 2026
SubstanceProduct
7417042*PED
Jan 20, 2027
7737112
Dec 7, 2027
Product
7737112*PED
Jun 7, 2028
RE47954
Oct 21, 2029
U-3449