NDAINJECTIONINJECTABLEPriority Review
Approved
Feb 1970
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Mechanism of Action
KETALAR, a racemic mixture of ketamine, is a non-selective, non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, an ionotropic glutamate receptor. The major circulating metabolite of ketamine (norketamine) demonstrated activity at the same receptor with less affinity. Norketamine…