KADIAN
LOE ApproachingNDAORALCAPSULE, EXTENDED RELEASE
Approved
Jul 1996
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
4/8 — Partial
KADIAN by AbbVie is clinical pharmacology morphine is a natural product that is the prototype for the class of natural and synthetic opioid analgesics. Approved for moderate to severe pain, around-the-clock opioid analgesic is needed for an extended period of time (see ). First approved in 1996.
Drug data last refreshed 4h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
KADIAN is an extended-release oral capsule formulation of morphine sulfate approved for moderate to severe pain requiring around-the-clock opioid analgesia over extended periods. It works as a pure mu-opioid receptor agonist that produces analgesia and sedation through activation of opioid receptors in the brain and spinal cord. The polymer-coated pellet technology delivers morphine more slowly than immediate-release formulations, providing steadier plasma levels with lower peak concentrations.
LOE Approaching
LOE-approaching product with moderate competitive pressure (30/100); declining brand team investment typical for aging extended-release morphine franchise.
Mechanism of Action
CLINICAL PHARMACOLOGY Morphine is a natural product that is the prototype for the class of natural and synthetic opioid analgesics. Opioids produce a wide spectrum of pharmacologic effects including analgesia, dysphoria, euphoria, somnolence, respiratory depression, diminished gastrointestinal…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.