JYNARQUE

Peak

tolvaptan

NDAORALTABLETPriority Review
Approved
Apr 2018
Lifecycle
Peak
Competitive Pressure
8/100
Clinical Trials
20

Mechanism of Action

Vasopressin V2 Receptor Antagonists

Pharmacologic Class:

Vasopressin V2 Receptor Antagonist

Clinical Trials (5)

NCT04782258Phase 3Recruiting

A Study to See Iftolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old withAutosomal Recessive Polycystic Kidney Disease (ARPKD)

Started Jan 2023
20 enrolled
Autosomal Recessive Polycystic Kidney (ARPKD)
NCT05190744Phase 2Completed

Probenecid (PB) to Treat Hereditary Nephrogenic Diabetes Insipidus (NDI), ADPKD Treated With Tolvaptan, and Severely Polyuric Patients With Previous Lithium Administration

Started Sep 2022
36 enrolled
Autosomal Dominant Polycystic Kidney DiseaseNephrogenic Diabetes InsipidusAcquired Nephrogenic Diabetes Insipidus+1 more
NCT04786574Phase 3Withdrawn

A Study to See if Tolvaptan Can Delay Dialysis in Infants and Children Who at Enrollment Are 28 Days to Less Than 12 Weeks Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)

Started Jul 2022
0
Autosomal Recessive Polycystic Kidney Disease (ARPKD)
NCT04331132N/AUnknown

Tolvaptan add-on Therapy to Overcome Loop Diuretic Resistance in Acute Heart Failure With Renal Dysfunction

Started Dec 2021
128 enrolled
Acute Heart Failure
NCT04152837Phase 3Terminated

Safety of Lixivaptan in Subjects Previously Treated With Tolvaptan for Autosomal Dominant Polycystic Kidney Disease

Started Sep 2020
7 enrolled
Polycystic Kidney Disease, AdultADPKD

Loss of Exclusivity

LOE Date
Apr 7, 2030
49 months away
Patent Expiry
Apr 7, 2030

Patent Records (2)

Patent #ExpiryTypeUse Code
8501730
Sep 1, 2026
Substance
10905694
Apr 7, 2030
Product