BLASUBCUTANEOUSINJECTABLE
Approved
Oct 2025
Lifecycle
Launch
Competitive Pressure
30/100
Data completeness
3/8 — Basic
JUBEREQ (denosumab-desu) by Accord Biopharma is rankl, a transmembrane or soluble protein essential for the formation, function, and survival of osteoclasts, the cells responsible for bone resorption, thereby modulating calcium release from bone. Approved for skeletal-related events in patients with multiple myeloma, skeletally mature adolescents with giant cell tumor of bone, where surgical resection is likely to result in severe morbidity [see clinical trials ()] and 1 more indications. First approved in 2025.
Drug data last refreshed 3h ago · AI intelligence enriched 5d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
JUBEREQ is a monoclonal antibody (denosumab-desu) that inhibits RANKL to suppress osteoclast formation and bone resorption. It is indicated for skeletal-related events in multiple myeloma, giant cell tumor of bone in skeletally mature adolescents, and hypercalcemia of malignancy refractory to bisphosphonate therapy. The mechanism prevents bone loss by blocking the RANK-RANKL signaling pathway critical to osteoclast survival and function.
Launch
Early-stage launch product with moderate competitive pressure (30/100), offering growth opportunities for commercial and medical affairs teams ramping market penetration.
Mechanism of Action
RANKL, a transmembrane or soluble protein essential for the formation, function, and survival of osteoclasts, the cells responsible for bone resorption, thereby modulating calcium release from bone. Increased osteoclast activity, stimulated by RANKL, is a mediator of bone pathology in solid tumors…
Worked on JUBEREQ at Accord Biopharma? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.