JAYPIRCA

PeakSM

pirtobrutinib

NDAORALTABLETPriority Review
Approved
Jan 2023
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
20

Mechanism of Action

Bruton's Tyrosine Kinase Inhibitors

Pharmacologic Class:

Kinase Inhibitor

Clinical Trials (5)

NCT07218341Phase 4Not Yet Recruiting

A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Started Mar 2026
150 enrolled
Chronic Lymphocytic LeukemiaLymphoma, Small Lymphocytic
NCT06948786Phase 2Recruiting

Pirtobrutinib and Mosunetuzumab for the Treatment of Relapsed/Refractory Grades 1-3A Follicular Lymphoma, PROMOTE-FL Trial

Started Nov 2025
22 enrolled
Grade 1 Follicular LymphomaGrade 2 Follicular LymphomaGrade 3a Follicular Lymphoma+2 more
NCT07231952Phase 2Recruiting

A Study of Pirtobrutinib, Venetoclax, and Rituximab in People With Waldenström's Macroglobulinemia (WM)/Lymphoplasmacytic Lymphoma (LPL)

Started Nov 2025
40 enrolled
Waldenstrom MacroglobulinemiaLymphoplasmacytic Lymphoma
NCT07285590Phase 2Recruiting

Clinical Trial to Evaluate the Efficacy and Safety of Pirtobrutinib With Rituximab in Patients With Mantle Cell Lymphoma

Started Sep 2025
50 enrolled
Mantle Cell Lymphoma (MCL)
NCT06973187Phase 3Recruiting

A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Started Sep 2025
500 enrolled
Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma

Loss of Exclusivity

LOE Date
Sep 14, 2041
189 months away
Patent Expiry
Sep 14, 2041
Exclusivity Expiry
Dec 1, 2030

Patent Records (5)

Patent #ExpiryTypeUse Code
10918622
Dec 16, 2036
U-4362
10464905
Dec 16, 2036
U-4362
10695323
Dec 16, 2036
SubstanceProduct
U-4362
10342780
Dec 16, 2036
SubstanceProduct
12220401
Dec 16, 2036
SubstanceProduct
U-4362