NDAORALTABLET
Approved
Mar 2007
Lifecycle
LOE Approaching
Competitive Pressure
15/100
Clinical Trials
4
Data completeness
7/8 — Comprehensive
JANUMET (sitagliptin and metformin hydrochloride) by Merck & Co. is 2 diabetes mellitus: sitagliptin, a dipeptidyl peptidase-4 (dpp-4) inhibitor, and metformin hcl, a member of the biguanide class. First approved in 2007.
Drug data last refreshed 18h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
JANUMET is a fixed-dose combination tablet containing sitagliptin (a DPP-4 inhibitor) and metformin HCl (a biguanide) approved by the FDA in March 2007 for the treatment of type 2 diabetes mellitus. Sitagliptin works by inhibiting dipeptidyl peptidase-4 to prolong the action of incretin hormones (GLP-1 and GIP), thereby increasing insulin release and decreasing glucagon levels in a glucose-dependent manner. Metformin improves insulin sensitivity and reduces hepatic glucose production and intestinal glucose absorption. JANUMET represents a foundational combination therapy in the type 2 diabetes treatment armamentarium, typically positioned as a second-line agent when monotherapy is insufficient.
$0.8BPart D
2.7 years to LOEMechanism of Action
2 diabetes mellitus: sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin HCl, a member of the biguanide class. Sitagliptin Sitagliptin is a DPP-4 inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones.…
Indications
Worked on JANUMET at Merck & Co.? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.