NDAORALTABLET
Approved
Mar 2007
Lifecycle
LOE Approaching
Competitive Pressure
15/100
Clinical Trials
4
Data completeness
6/8 — Strong
JANUMET (sitagliptin and metformin hydrochloride) by Merck & Co. is 2 diabetes mellitus: sitagliptin, a dipeptidyl peptidase-4 (dpp-4) inhibitor, and metformin hcl, a member of the biguanide class. First approved in 2007.
Drug data last refreshed 34m ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
JANUMET is a fixed-dose oral combination of sitagliptin (a DPP-4 inhibitor) and metformin hydrochloride (a biguanide) approved for type 2 diabetes mellitus. Sitagliptin slows inactivation of incretin hormones (GLP-1 and GIP) to increase insulin release and lower glucagon in a glucose-dependent manner, while metformin decreases hepatic glucose production and improves insulin sensitivity. Together, they address multiple pathways of hyperglycemia in type 2 diabetes patients.
$0.799BPart D
LOE ApproachingStable
2.2 years to LOEWith 2.3 years until LOE and 776K annual claims, the brand team is transitioning from growth maintenance to LOE defense and lifecycle extension strategies.
Mechanism of Action
2 diabetes mellitus: sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin HCl, a member of the biguanide class. Sitagliptin Sitagliptin is a DPP-4 inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones.…
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.