NDAORALTABLET
Approved
Mar 2007
Lifecycle
LOE Approaching
Competitive Pressure
15/100
Clinical Trials
4
Data completeness
6/8 — Strong
JANUMET (sitagliptin and metformin hydrochloride) by Merck & Co. is 2 diabetes mellitus: sitagliptin, a dipeptidyl peptidase-4 (dpp-4) inhibitor, and metformin hcl, a member of the biguanide class. First approved in 2007.
Drug data last refreshed 15h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
JANUMET is a fixed-dose oral combination tablet containing sitagliptin (a DPP-4 inhibitor) and metformin hydrochloride (a biguanide) for treating type 2 diabetes mellitus. Sitagliptin slows inactivation of incretin hormones (GLP-1 and GIP) to increase insulin release and decrease glucagon in a glucose-dependent manner, while metformin decreases hepatic glucose production and improves insulin sensitivity. Together, they provide complementary mechanisms to lower fasting and postprandial plasma glucose.
$0.8BPart D
LOE Approaching2.5 years to LOEProduct is approaching loss of exclusivity in 2.5 years with 776K+ Part D claims; brand team focus will shift toward defending market share and managing transition planning.
Mechanism of Action
2 diabetes mellitus: sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin HCl, a member of the biguanide class. Sitagliptin Sitagliptin is a DPP-4 inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones.…
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.