NDAORALGRANULE2 Generics Approved
Approved
May 2017
Lifecycle
Peak
Competitive Pressure
60/100
Clinical Trials
20
Data completeness
6/8 — Strong
JADENU SPRINKLE (deferasirox) by Novartis is iron chelating activity [moa]. Approved for iron chelator [epc]. First approved in 2017.
Drug data last refreshed 23h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
JADENU SPRINKLE is an oral iron chelator containing deferasirox in granule form, approved by the FDA in May 2017. It removes excess iron from the body in patients with transfusional iron overload and related conditions. The drug works by binding iron and facilitating its excretion, addressing a critical complication of chronic blood transfusions.
$0.555MPart D
PeakProduct is at peak lifecycle with modest Medicare Part D penetration (37 claims, $555K spending in 2023), suggesting a stable but niche commercial footprint with limited team expansion opportunity.
Mechanism of Action
Iron Chelating Activity
Pharmacologic Class:
Iron Chelator
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Early and Low Dose Deferasirox (3.5 mg/kg FCT) to Suppress NTBI and LPI as Early Intervention to Prevent Tissue Iron Overload in Lower Risk MDS
Started Oct 2019
11 enrolled
Myelodysplastic Syndromes
Evaluating Low-dose Deferasirox (DFX) in Patients With Low-risk MDS Resistant or Relapsing After ESA Agents
Started Feb 2018
39 enrolled
Myelodysplasia
Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis
Started Jan 2018
44 enrolled
Iron Overload
Study to Evaluate the Efficacy and Safety of Deferasirox Film-coated Tablet Versus Phlebotomy in Patients With Hereditary Hemochromatosis (HH)
Started Jan 2018
45 enrolled
Hereditary Hemochromatosis
Open-label, Multicenter Study Assessing Preference for Deferasirox Film-coated Tablet Compared to Dispersible Tablet
Started Jul 2017
148 enrolled
Transfusion-dependent ThalassemiaNon-transfusion-dependent Thalassemia
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.