IWILFIN
LOE Approachingeflornithine hydrochloride
NDAORALTABLETPriority Review
Approved
Dec 2023
Lifecycle
LOE Approaching
Competitive Pressure
35/100
Mechanism of Action
(ODC), the first and rate-limiting enzyme in the biosynthesis of polyamines and a transcriptional target of MYCN . Polyamines are involved in differentiation and proliferation of mammalian cells and are important for neoplastic transformation. Inhibition of polyamine synthesis by eflornithine…
Loss of Exclusivity
LOE Date
Dec 13, 2026
9 months away
Exclusivity Expiry
Dec 13, 2030