NDAOPHTHALMICSOLUTION/DROPS
Approved
Jun 2004
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
9
Data completeness
5/8 — Partial
ISTALOL (timolol maleate) by Bausch + Lomb is 1 and beta 2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. First approved in 2004.
Drug data last refreshed 10h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ISTALOL is a topical ophthalmic solution containing timolol maleate, a non-selective beta-adrenergic receptor antagonist approved for reducing intraocular pressure in glaucoma and ocular hypertension. The drug works primarily by reducing aqueous humor formation, with onset within 30 minutes and peak effect in 1-2 hours, maintaining efficacy for up to 24 hours per dose. It is a mature small-molecule product indicated for chronic eye pressure management.
$0.803MPart D
LOE ApproachingDeclining
Product is approaching loss of exclusivity with minimal Part D claims, indicating a contracting brand team and reduced commercial expansion opportunities.
Mechanism of Action
1 and beta 2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. Beta-adrenergic receptor blockade reduces cardiac output in both healthy subjects and patients…
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.