NDAOPHTHALMICSOLUTION/DROPSPriority Review
Approved
Jun 2010
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Mechanism of Action
glands. Pilocarpine contracts the ciliary muscle, causing increased tension on the scleral spur and opening of the trabecular meshwork spaces to facilitate outflow of aqueous humor. Outflow resistance is reduced, lowering IOP. Pilocarpine also produces miosis through contraction of the iris…