ISMOTIC
LOE ApproachingNDAORALSOLUTION
Approved
Jan 1974
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
ISMOTIC by Alcon is clinical pharmacology isosorbide is rapidly absorbed after oral administration. First approved in 1974.
Drug data last refreshed 11h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ISMOTIC (isosorbide) is an oral osmotic agent approved in 1974 that works by promoting water redistribution toward the circulation for elimination via the kidney. It is a small-molecule, non-metabolized compound used to manage conditions requiring osmotic diuresis. The drug acts through physical osmotic action similar to other agents in its class.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30%), signaling a shrinking brand team and transition toward maintenance mode.
Mechanism of Action
CLINICAL PHARMACOLOGY Isosorbide is rapidly absorbed after oral administration. It is essentially nonmetabolized, and in the circulation, it contributes to the tonicity of the blood until it is eliminated by the kidney unchanged. While in the blood, isosorbide acts as an osmotic agent to promote…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
Working on ISMOTIC offers limited career growth or advancement given its LOE-approaching status and absence of linked job openings. Roles available are primarily maintenance-focused, with minimal innovation or clinical depth.
Brand Manager
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.