ISMOTIC
LOE ApproachingNDAORALSOLUTION
Approved
Jan 1974
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
ISMOTIC by Alcon is clinical pharmacology isosorbide is rapidly absorbed after oral administration. First approved in 1974.
Drug data last refreshed 9h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ISMOTIC (isosorbide) is an oral osmotic agent approved in 1974 that acts by promoting water redistribution from tissues toward the circulation for renal elimination. It is used to reduce intraocular pressure, primarily in ophthalmology. The drug works through passive osmotic action without metabolism, contributing directly to blood tonicity.
LOE Approaching
Product approaching loss of exclusivity with modest competitive pressure (30/100), indicating shrinking brand team resources and transition to generic-era support model.
Mechanism of Action
CLINICAL PHARMACOLOGY Isosorbide is rapidly absorbed after oral administration. It is essentially nonmetabolized, and in the circulation, it contributes to the tonicity of the blood until it is eliminated by the kidney unchanged. While in the blood, isosorbide acts as an osmotic agent to promote…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
ISMOTIC offers minimal career growth potential given its LOE-approaching status and zero linked job postings. Roles on this product focus on maintaining compliance, managing generic transition, and supporting legacy customers rather than building market share or developing new therapies.
Medical Affairs
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.