IOPIDINE
LOE Approachingapraclonidine hydrochloride ophthalmic solution
NDAOPHTHALMICSOLUTION/DROPS
Approved
Dec 1987
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
IOPIDINE (apraclonidine hydrochloride ophthalmic solution) is apraclonidine is a relatively selective, alpha adrenergic agonist and does not have significant membrane stabilizing (local anesthetic) activity. First approved in 1987.
Drug data last refreshed 2d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
IOPIDINE is an ophthalmic solution containing apraclonidine hydrochloride, a selective alpha-2-adrenergic agonist that reduces intraocular pressure (IOP) by decreasing aqueous humor formation. It is indicated for preventing or controlling acute IOP elevation following laser eye surgery (argon laser trabeculoplasty, iridotomy, and Nd:YAG capsulotomy) and for managing ocular redness in glaucoma patients. The drug demonstrates onset of action within one hour with maximum IOP reduction typically occurring 3-5 hours after application.
$0.105MPart D
LOE ApproachingDeclining
With approaching loss of exclusivity and minimal Part D spending, IOPIDINE is in the late commercial stage with likely reduced brand team headcount and transition toward generic support.
Mechanism of Action
Apraclonidine is a relatively selective, alpha adrenergic agonist and does not have significant membrane stabilizing (local anesthetic) activity. When instilled into the eye, IOPIDINE 1% (apraclonidine hydrochloride ophthalmic solution) has the action of reducing intraocular pressure (IOP).…
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.