NDAORALCAPSULE, EXTENDED RELEASE
Approved
Mar 2003
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Mechanism of Action
established. Among factors that contribute to the antihypertensive action are: (1) decreased cardiac output, (2) inhibition of renin release by the kidneys, and (3) diminution of tonic sympathetic nerve outflow from vasomotor centers in the brain. Although total peripheral resistance may increase…