NDAORALCAPSULE, EXTENDED RELEASE
Approved
Apr 1983
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
3
Data completeness
5/8 — Partial
INDERAL LA (propranolol hydrochloride) by ANI Pharmaceuticals is clinical pharmacology general propranolol is a nonselective, beta-adrenergic receptor-blocking agent possessing no other autonomic nervous system activity. First approved in 1983.
Drug data last refreshed 7h ago · AI intelligence enriched 4d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
INDERAL LA (propranolol hydrochloride) is a nonselective beta-adrenergic receptor-blocking agent in extended-release capsule form, approved since 1983 for oral use. It treats hypertension, angina pectoris, and cardiac arrhythmias by competitively blocking beta-receptor sites and reducing cardiac output, heart rate, and oxygen demand. The extended-release formulation provides 24-hour efficacy with once-daily dosing, though blood levels are lower than conventional propranolol dosed multiple times daily.
$8MPart D
LOE ApproachingMature product approaching loss of exclusivity with modest Part D spending signals a contracting brand team focused on maintaining market share against generics.
Mechanism of Action
CLINICAL PHARMACOLOGY General Propranolol is a nonselective, beta-adrenergic receptor-blocking agent possessing no other autonomic nervous system activity. It specifically competes with beta-adrenergic receptor-stimulating agents for available receptor sites. When access to beta-receptor sites is…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.