NDAORALCAPSULE, EXTENDED RELEASE
Approved
Apr 1983
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
5/8 — Partial
INDERAL LA (propranolol hydrochloride) by ANI Pharmaceuticals is clinical pharmacology general propranolol is a nonselective, beta-adrenergic receptor-blocking agent possessing no other autonomic nervous system activity. First approved in 1983.
Drug data last refreshed 4h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
INDERAL LA (propranolol hydrochloride) is a nonselective beta-adrenergic receptor blocker available as an extended-release oral capsule, approved in 1983. It works by blocking beta-adrenergic receptor sites, reducing cardiac output, heart rate, and blood pressure; used clinically for hypertension, angina pectoris, arrhythmias, and various off-label indications. The extended-release formulation provides once-daily dosing with lower blood levels than immediate-release propranolol but maintains 24-hour therapeutic equivalence in most clinical settings.
$8MPart D
LOE ApproachingDeclining
Product approaching loss of exclusivity with modest Medicare spending ($8M in 2023) signals a consolidating market with reduced career growth opportunity in commercial teams.
Mechanism of Action
CLINICAL PHARMACOLOGY General Propranolol is a nonselective, beta-adrenergic receptor-blocking agent possessing no other autonomic nervous system activity. It specifically competes with beta-adrenergic receptor-stimulating agents for available receptor sites. When access to beta-receptor sites is…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.