BLASUBCUTANEOUSINJECTABLEPriority Review
Approved
Aug 2005
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
3
Data completeness
5/8 — Partial
Priority Review
INCRELEX (mecasermin) by Ipsen is insulin-like growth factor-1 (igf-1) is a key hormonal mediator on statural growth. Approved for insulin-like growth factor-1 deficiency, growth disorders, growth hormone insensitivity syndrome. First approved in 2005.
Drug data last refreshed Yesterday · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
INCRELEX (mecasermin) is a recombinant human insulin-like growth factor-1 (IGF-1) replacement therapy administered via subcutaneous injection. It treats growth disorders including IGF-1 deficiency and growth hormone insensitivity syndrome by activating Type 1 IGF-1 receptors to stimulate statural growth and metabolic support. The drug directly replaces deficient IGF-1, bypassing the need for growth hormone signaling in GH-insensitive patients.
LOE Approaching
Product approaching loss of exclusivity signals transition from growth-focused to defensive commercial strategy; team size likely stable but shifting toward retention and lifecycle management.
Mechanism of Action
Insulin-like growth factor-1 (IGF-1) is a key hormonal mediator on statural growth. Under normal circumstances, growth hormone (GH) binds to its receptor in the liver, and other tissues, and stimulates the synthesis/secretion of IGF-1. In target tissues, the Type 1 IGF-1 receptor, which is…
Indications (3)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.