NDAORALTABLET, CHEWABLE
Approved
Jul 1997
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
3/8 — Basic
IMODIUM A-D EZ CHEWS (loperamide hydrochloride) by Johnson & Johnson is mechanism of action in vitro and animal studies show that loperamide hydrochloride capsules act by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. First approved in 1997.
Drug data last refreshed 1h ago · AI intelligence enriched 6h ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
IMODIUM A-D EZ CHEWS is a chewable tablet formulation of loperamide hydrochloride, an oral antidiarrheal agent that works by slowing intestinal motility and reducing propulsive peristalsis through opiate receptor binding in the gut wall. It is indicated for symptomatic relief of acute diarrhea and reduces urgency and incontinence by increasing anal sphincter tone. The drug represents a convenient dosage form of a well-established, over-the-counter antidiarrheal mechanism.
LOE Approaching
As LOE approaches, the brand team is likely focused on line extension, cost management, and transition planning rather than growth initiatives.
Mechanism of Action
Mechanism of Action In vitro and animal studies show that loperamide hydrochloride capsules act by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. Loperamide binds to the opiate receptor in the gut wall. Consequently, it inhibits the release of…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (2)
A Study of Combination Caplet With Loperamide Hydrochloride and Simethicone, and Imodium Express Tablets-lyophilizate Coadministered With Espumisan Capsule in Healthy Volunteers
Started Dec 2019
48 enrolled
Healthy
Efficacy and Safety Study of Loperamide Hydrochloride/Simethicone Chewable Tablet in Treatment of Acute Diarrhea With Abdominal Discomfort and Flatulence
Started Jul 2005
217 enrolled
Diarrhea
Career Relevance
Working on IMODIUM A-D EZ CHEWS offers limited career growth given the product's LOE-approaching lifecycle and minimal linked job postings. This role is best suited for professionals seeking mature-product management experience, cost-optimization expertise, or a stepping stone to higher-growth brands within Johnson & Johnson's portfolio.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.