IMJUDO
PeakmAbBLAINTRAVENOUSINJECTABLE
Approved
Nov 2022
Lifecycle
Peak
Competitive Pressure
30/100
Clinical Trials
3
Data completeness
5/8 — Partial
IMJUDO by AstraZeneca is ctla-4 is a negative regulator of t-cell activity. Approved for anaplastic lymphoma kinase (alk) genomic tumor aberrations. First approved in 2022.
Drug data last refreshed Yesterday · AI intelligence enriched Yesterday
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
IMJUDO (tremelimumab-actl) is a monoclonal antibody that blocks CTLA-4, a negative regulator of T-cell immunity, to treat ALK-positive anaplastic lymphoma kinase genomic tumor aberrations. By releasing CTLA-4-mediated inhibition, it enhances T-cell activation and proliferation within tumors. It is administered intravenously as part of AstraZeneca's immuno-oncology portfolio.
$0.002BPart D
PeakEarly-stage peak product with modest Part D penetration (65 claims in 2023) suggests active commercial expansion and team growth opportunities in oncology.
Mechanism of Action
CTLA-4 is a negative regulator of T-cell activity. Tremelimumab-actl is a monoclonal antibody that binds to CTLA-4 and blocks the interaction with its ligands CD80 and CD86, releasing CTLA-4-mediated inhibition of T-cell activation. In synergistic mouse tumor models, blocking CTLA-4 activity…
Indications (1)
Clinical Trials (3)
Imjudo & Imfinzi PMS
Started Apr 2025
246 enrolled
Hepatocellular Carcinoma
Imfinzi/Imjudo NSCLC Japan PMS_Japan Post-Marketing Surveillance (PMS) Study - CEI/SCEI
Started Jun 2023
296 enrolled
Carcinoma, Non-Small-Cell Lung
Imfinzi/Imjudo uHCC Japan PMS _ Japan Post-Marketing Surveillance (PMS) Study
Started May 2023
1,200 enrolled
Unresectable Hepatocellular Carcinoma
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.