HYZAAR

LOE Approaching

losartan potassium and hydrochlorothiazide

NDAORALTABLET
Approved
Apr 1995
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2

Mechanism of Action

[formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE, kininase II)], is a potent vasoconstrictor, the primary vasoactive hormone of the renin-angiotensin system and an important component in the pathophysiology of hypertension. It also stimulates aldosterone…

Pharmacologic Class:

Thiazide Diuretic

Clinical Trials (2)

NCT00354991Phase 3Completed

Hyzaar Asia HEAALTH (0954A-950)

Started Jun 2006
437 enrolled
Hypertension
NCT00234858Phase 4Completed

Tarka vs. Hyzaar in Patients With Metabolic Syndrome (STAR)

Started Mar 2004
280 enrolled
HypertensionMetabolic Syndrome