NDAORALTABLET
Approved
Feb 1959
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
3/8 — Basic
HYDRODIURIL (hydrochlorothiazide) by Merck & Co. is reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. First approved in 1959.
Drug data last refreshed 21h ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
HYDRODIURIL (hydrochlorothiazide) is a thiazide diuretic oral tablet approved in 1959 for hypertension and essential hypertension. It works by inhibiting renal tubular reabsorption of sodium and chloride, increasing their urinary excretion and reducing plasma volume to lower blood pressure. The exact antihypertensive mechanism is not fully understood but involves indirect effects on the renin-aldosterone system.
LOE Approaching
HYDRODIURIL operates in a mature, highly competitive market with moderate competitive pressure (30/100) and faces significant displacement by newer agents, suggesting consolidation of commercial teams around LOE defense and niche positioning.
Mechanism of Action
reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
A Study to Learn How the Body Processes Spironolactone and Hydrochlorothiazide Film Coated Tablets Manufactured at Two Sites: Viatris and Neolpharma
Started Dec 2023
42 enrolled
Healthy Participants
Comparison of the Medication Adherence of Patients Treated With Telmisartan/Hydrochlorothiazide or Telmisartan/Amlodipine Fixed Dose Combination (FDC) Versus Double-pill Combination Therapy in Real-world Japanese Therapeutic Practice
Started Jun 2022
0Hypertension
Ertugliflozin Versus Hydrochlorothiazide in Reducing Sympathetic Neural Overactivity in Patients With Hypertension and Recently-diagnosed Type 2 Diabetes.
Started Sep 2018
0HypertensionDiabetes Mellitus, Type 2
A Drug to Drug Interaction Study of Sotagliflozin With Hydrochlorothiazide
Started Jan 2018
16 enrolled
Type 2 Diabetes Mellitus
Bioequivalence Study Between GSK3542503 Hydrochlorothiazide + Amiloride Hydrochloride 50 mg: 5 mg Tablets and Reference Product in Healthy Adult Participants Under Fasting Conditions
Started Mar 2017
42 enrolled
Hypertension
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.