HORIZANT

Peak

gabapentin enacarbil

NDAORALTABLET, EXTENDED RELEASE
Approved
Apr 2011
Lifecycle
Peak
Competitive Pressure
8/100
Clinical Trials
3

Mechanism of Action

and, accordingly, its therapeutic effects in RLS and PHN are attributable to gabapentin. The precise mechanism by which gabapentin is efficacious in RLS and PHN is unknown. The mechanism of action by which gabapentin is efficacious in PHN is unknown but in animal models of analgesia, gabapentin…

Clinical Trials (3)

NCT03053427Phase 4Completed

A Study of Oral Dosing of Gabapentin Enacarbil in Japanese Restless Legs Syndrome Patients

Started Mar 2017
375 enrolled
Restless Legs Syndrome (RLS)
NCT01981941Phase 4Completed

Post-marketing Study of Gabapentin Enacarbil to Evaluate the Effect in Restless Leg Syndrome (RLS) Patients With Moderate Renal Impairment

Started Nov 2013
19 enrolled
Restless Legs Syndrome (RLS)
NCT02658188Phase 3Completed

Long-term Efficacy and Safety of Gabapentin Enacarbil in Japanese Restless Legs Syndrome Patients

Started Dec 2007
182 enrolled
Restless Legs Syndrome

Loss of Exclusivity

LOE Date
Jun 10, 2029
39 months away
Patent Expiry
Jun 10, 2029

Patent Records (3)

Patent #ExpiryTypeUse Code
8114909
Apr 11, 2026
U-1231
8026279
Nov 10, 2026
SubstanceProduct
8795725
Jun 10, 2029
Product
U-1247