HISTAMINE PHOSPHATE
LOE ApproachingNDAINJECTIONINJECTABLE
Approved
Apr 1939
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
HISTAMINE PHOSPHATE by Eli Lilly and Company is clinical pharmacology histamine acts as a potent vasodilator when released from mast cells during an allergic reaction. First approved in 1939.
Drug data last refreshed 4h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Histamine Phosphate is an injectable small molecule diagnostic agent that acts as a potent vasodilator to provoke immediate skin reactions in allergy testing. It is used to assess histamine responsiveness and mast cell degranulation in patients suspected of allergic conditions. The drug works by mimicking endogenous histamine release, producing characteristic wheal-and-flare reactions that aid in allergen identification.
LOE Approaching
As a legacy diagnostic agent approaching loss of exclusivity with minimal Part D spending data, the commercial team is likely small and focused on maintaining niche allergy diagnostic market share.
Mechanism of Action
CLINICAL PHARMACOLOGY Histamine acts as a potent vasodilator when released from mast cells during an allergic reaction. It is largely responsible for the immediate skin test reaction of a sensitive patient when challenged with an offending allergen. The effect of added Glycerin (50% v/v) to 1 mg/mL…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
Working on Histamine Phosphate offers minimal career growth opportunity given the product's 85-year legacy status, approaching LOE, and zero linked job openings. This role is suited for professionals seeking stability in a niche diagnostic market rather than rapid advancement or launch experience.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.