HERNEXEOS

Launch

zongertinib

NDAORALTABLETPriority Review
Approved
Aug 2025
Lifecycle
Launch
Competitive Pressure
0/100
Clinical Trials
13

Mechanism of Action

HER2/Neu/cerbB2 Antagonists

Pharmacologic Class:

Kinase Inhibitor

Clinical Trials (5)

NCT07195695Phase 3Recruiting

Beamion LUNG-3: A Study to Test Whether Zongertinib Helps People With Surgically Removed, Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment

Started Jan 2026
400 enrolled
Non-small Cell Lung Cancer
NCT06692322Phase 1Completed

A Study to Test How Zongertinib is Taken up in the Blood of People With and Without Liver Problems

Started Jan 2025
29 enrolled
Liver DiseasesHealthy
NCT06581432Phase 2Recruiting

Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations

Started Oct 2024
430 enrolled
Solid Tumours
NCT06504862Phase 1Completed

A Study in Healthy Men to Test Whether Zongertinib Influences the Amount of 4 Other Medicines (Dabigatran, Rosuvastatin, Metformin, and Furosemide) in the Blood

Started Aug 2024
32 enrolled
Healthy
NCT06494761Phase 1Completed

A Study in Healthy Men to Test Whether Zongertinib Affects How 3 Other Medicines (Midazolam, Omeprazole, and Repaglinide) Are Taken up and Processed by the Body

Started Jul 2024
16 enrolled
Healthy

Loss of Exclusivity

LOE Date
Jul 21, 2041
187 months away
Patent Expiry
Jul 21, 2041
Exclusivity Expiry
Aug 8, 2030

Patent Records (2)

Patent #ExpiryTypeUse Code
12171739
Nov 15, 2026
SubstanceProduct
11608343
Jul 21, 2041
SubstanceProduct
U-4245