HEMICLOR

Growth

chlorthalidone

NDAORALTABLET
Approved
Mar 2025
Lifecycle
Growth
Competitive Pressure
30/100
Clinical Trials
9

Mechanism of Action

long-acting oral diuretic with antihypertensive activity. Chlorthalidone produces diuresis with increased excretion of sodium and chloride. The site of action appears to be the cortical diluting segment of the ascending limb of Henle's loop of the nephron. The diuretic effects of chlorthalidone…

Pharmacologic Class:

Thiazide-like Diuretic

Clinical Trials (5)

NCT01456169Phase 3Completed

A Study to Evaluate the Effectiveness and Safety of a Fixed Dose Combination of Azilsartan Medoxomil and Chlorthalidone in Patients With High Blood Pressure Who do Not Achieve Target Blood Pressure Following Treatment With Azilsartan Medoxomil Alone

Started Oct 2011
507 enrolled
Essential Hypertension
NCT01368536Phase 4Terminated

Study to Evaluate the Efficacy and Safety of the Combination of Valturna and Amlodipine or Valturna and Chlorthalidone Versus Valturna Alone in Patients With Stage 2 Hypertension and Diabetes

Started May 2011
975 enrolled
HypertensionStage 2 HypertensionDiabetes
NCT01309828Phase 3Completed

Long-Term Safety of Azilsartan Medoxomil and Chlorthalidone Compared to Olmesartan Medoxomil and Hydrochlorothiazide in Participants With Hypertension and Kidney Disease

Started Mar 2011
153 enrolled
Safety
NCT01033071Phase 3Completed

Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone Compared to Olmesartan Medoxomil and Hydrochlorothiazide in Participants With Moderate to Severe Hypertension.

Started Jan 2010
1,071 enrolled
Essential Hypertension
NCT00996281Phase 3Completed

Safety and Tolerability of Azilsartan Medoxomil Plus Chlorthalidone Compared to Olmesartan Medoxomil Plus Hydrochlorothiazide in Participants With Essential Hypertension

Started Oct 2009
837 enrolled
Essential Hypertension