NDAINJECTIONINJECTABLE
Approved
Jan 1979
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
HEMABATE (carboprost tromethamine) by Pfizer is clinical pharmacology carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy. Approved for postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management. First approved in 1979.
Drug data last refreshed 8h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
HEMABATE (carboprost tromethamine) is a prostaglandin analog administered intramuscularly to treat postpartum hemorrhage due to uterine atony that has not responded to conventional management. It works by stimulating myometrial contractions similar to labor contractions, which evacuate products of conception and provide hemostasis at the placentation site.
LOE Approaching
Product approaching loss of exclusivity with limited current job demand; commercial teams likely focused on transition planning and niche market maintenance rather than growth initiatives.
Mechanism of Action
CLINICAL PHARMACOLOGY Carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy. Whether or not these contractions result from a direct effect of carboprost on the myometrium has not…
Worked on HEMABATE at Pfizer? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.