NDAINJECTIONINJECTABLE
Approved
Jan 1979
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
HEMABATE (carboprost tromethamine) by Pfizer is clinical pharmacology carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy. Approved for postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management. First approved in 1979.
Drug data last refreshed 17h ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
HEMABATE (carboprost tromethamine) is a prostaglandin analog administered intramuscularly that stimulates uterine myometrial contractions to manage postpartum hemorrhage refractory to conventional treatments. It works by directly contracting uterine smooth muscle to achieve hemostasis at the placentation site. The drug is indicated specifically for postpartum hemorrhage due to uterine atony when standard interventions have failed.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30%), indicating contraction phase for commercial teams.
Mechanism of Action
CLINICAL PHARMACOLOGY Carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy. Whether or not these contractions result from a direct effect of carboprost on the myometrium has not…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.