NDAINJECTIONINJECTABLE
Approved
Jan 1979
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
HEMABATE (carboprost tromethamine) by Pfizer is clinical pharmacology carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy. Approved for postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management. First approved in 1979.
Drug data last refreshed 11h ago · AI intelligence enriched 5d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
HEMABATE (carboprost tromethamine) is a small-molecule prostaglandin analog administered via intramuscular injection that stimulates uterine myometrial contractions to evacuate the products of conception or provide hemostasis postpartum. It is indicated for postpartum hemorrhage due to uterine atony when conventional management has failed. The drug works by directly stimulating smooth muscle contraction in the gravid uterus, similar to labor contractions.
LOE Approaching
Product is approaching loss of exclusivity with minimal current commercial momentum, suggesting small, defensive brand team focused on retained market share rather than growth initiatives.
Mechanism of Action
CLINICAL PHARMACOLOGY Carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy. Whether or not these contractions result from a direct effect of carboprost on the myometrium has not…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.