NDAORALCAPSULE, EXTENDED RELEASE
Approved
Aug 2017
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
14
Data completeness
6/8 — Strong
GOCOVRI (amantadine) by Supernus Pharmaceuticals is m2 protein inhibitors [moa]. First approved in 2017.
Drug data last refreshed 23m ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
GOCOVRI is an extended-release oral capsule formulation of amantadine, an M2 protein inhibitor originally developed for influenza A. The drug is indicated for use in Parkinson's disease patients experiencing levodopa-induced dyskinesia, working through dopaminergic and glutamatergic mechanisms distinct from its antiviral heritage.
$0.092BPart D
Peak11.9 years to LOEProduct is at peak sales maturity with $92M in Part D spending and no direct competitors, indicating a stable, defensible market position that supports a focused brand and medical affairs team.
Mechanism of Action
M2 Protein Inhibitors
Pharmacologic Class:
Influenza A M2 Protein Inhibitor
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (14)
Use of Gocovri to Improve Disability Due to Radiation Encephalopathy
Started Sep 2025
24 enrolled
Radiation Encephalopathy
Acetyl-Amantadine as a Biomarker in Patients With Glioblastoma
Started Dec 2020
20 enrolled
Glioblastoma Multiforme
Effect of GOCOVRI (Amantadine, Extended Release Capsules) on Gait in Parkinson's Disease
Started Nov 2020
8 enrolled
Parkinson Disease
Buspirone, in Combination With Amantadine, for the Treatment of Levodopa-induced Dyskinesia
Started Jan 2016
6 enrolled
Parkinson's DiseaseDyskinesiasMovement Disorders
Effect of Intravenous Amantadine on Gait Freezing in Parkinson's Disease
Started Feb 2011
46 enrolled
Parkinson's Disease
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.