NDAORALCAPSULE, EXTENDED RELEASE
Approved
Aug 2017
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
14
Data completeness
6/8 — Strong
GOCOVRI (amantadine) by Supernus Pharmaceuticals is m2 protein inhibitors [moa]. First approved in 2017.
Drug data last refreshed 22m ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
GOCOVRI is an extended-release oral capsule formulation of amantadine, an M2 protein inhibitor originally developed for influenza A. It is indicated for Parkinson's disease and levodopa-induced dyskinesia, leveraging amantadine's mechanism to reduce motor complications in advanced PD patients. The extended-release formulation improves dosing convenience and tolerability compared to immediate-release alternatives.
$92MPart D
Peak12.2 years to LOEProduct is at peak commercial maturity with ~$92M annual Part D spending, indicating a stable, mature franchise with established market penetration and predictable team staffing needs.
Mechanism of Action
M2 Protein Inhibitors
Pharmacologic Class:
Influenza A M2 Protein Inhibitor
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (14)
Use of Gocovri to Improve Disability Due to Radiation Encephalopathy
Started Sep 2025
24 enrolled
Radiation Encephalopathy
Acetyl-Amantadine as a Biomarker in Patients With Glioblastoma
Started Dec 2020
20 enrolled
Glioblastoma Multiforme
Effect of GOCOVRI (Amantadine, Extended Release Capsules) on Gait in Parkinson's Disease
Started Nov 2020
8 enrolled
Parkinson Disease
Buspirone, in Combination With Amantadine, for the Treatment of Levodopa-induced Dyskinesia
Started Jan 2016
6 enrolled
Parkinson's DiseaseDyskinesiasMovement Disorders
Effect of Intravenous Amantadine on Gait Freezing in Parkinson's Disease
Started Feb 2011
46 enrolled
Parkinson's Disease
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.