GLEEVEC

LOE Approaching

imatinib mesylate

NDAORALTABLETPriority Review
Approved
Apr 2003
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
155

Mechanism of Action

protein-tyrosine kinase inhibitor that inhibits the BCR-ABL tyrosine kinase, the constitutive abnormal tyrosine kinase created by the Philadelphia chromosome abnormality in CML. Imatinib inhibits proliferation and induces apoptosis in BCR-ABL positive cell lines as well as fresh leukemic cells from…

Clinical Trials (5)

NCT05413915Phase 3Active Not Recruiting

Asciminib Used in Consolidation With Imatinib vs. Imatinib to Achieve TFR in CP-CML

Started Nov 2023
164 enrolled
Chronic Myeloid LeukemiaChronic Myeloid Leukemia, BCR/ABL-PositiveChronic Myeloid Leukemia in Remission
NCT05623774Phase 1Completed

A Dose Calibration Study Comparing IkT-001Pro to Imatinib Mesylate 400mg

Started Dec 2022
64 enrolled
CML
NCT04877522Phase 4Recruiting

Asciminib Roll-over Study

Started Aug 2022
347 enrolled
Chronic Myelogenous LeukemiaLeukemia, Myelogenous, Chronic, BCR-ABL Positive
NCT04971226Phase 3Active Not Recruiting

A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP

Started Oct 2021
406 enrolled
Chronic Myeloid Leukemia (CML) Philadelphia Chromosome Positive
NCT04546074Phase 1/2Unknown

Imatinib Mesylate in Combination With Pembrolizumab in Patients With Melanoma

Started Sep 2020
22 enrolled
Melanoma