NDATRANSDERMALGEL
Approved
Jan 2009
Lifecycle
Peak
Competitive Pressure
8/100
Clinical Trials
3
Data completeness
5/8 — Partial
GELNIQUE (oxybutynin chloride) by AbbVie is clinical pharmacology oxybutynin chloride exerts a direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. First approved in 2009.
Drug data last refreshed 3h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
GELNIQUE is a transdermal gel formulation of oxybutynin chloride, an anticholinergic agent that relaxes bladder smooth muscle by inhibiting muscarinic acetylcholine activity. It treats overactive bladder (OAB) characterized by involuntary detrusor contractions, reducing urgency, incontinence episodes, and urinary frequency. The R-isomer of oxybutynin provides the primary antimuscarinic effect, with a metabolite (desethyloxybutynin) contributing additional pharmacological activity.
$0.816MPart D
Peak4.8 years to LOEProduct is at peak commercial maturity with modest Part D spending ($816K, 1,113 claims in 2023), indicating stable but limited growth trajectory for a mature franchise.
Mechanism of Action
CLINICAL PHARMACOLOGY Oxybutynin chloride exerts a direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. Oxybutynin chloride exhibits only one fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.