NDAORALTABLET
Approved
Sep 1994
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
3/8 — Basic
FUROSEMIDE (furosemide) by R-Pharm US is clinical pharmacology investigations into the mode of action of furosemide have utilized micropuncture studies in rats, stop flow experiments in dogs and various clearance studies in both humans and experimental animals. First approved in 1994.
Drug data last refreshed 3h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Furosemide is a loop diuretic that inhibits sodium and chloride reabsorption primarily in the loop of Henle, proximal and distal tubules, making it one of the most potent diuretic agents available. It is indicated for management of edema associated with congestive heart failure, renal disease, and hepatic cirrhosis, as well as hypertension. The drug works through a unique site of action independent of carbonic anhydrase inhibition, resulting in rapid onset (5 minutes IV, somewhat later IM/oral) and peak effect within 30 minutes.
LOE Approaching
Product is in late-stage life cycle with LOE approaching; commercial team size likely stabilized or consolidating as generic competition intensifies.
Mechanism of Action
CLINICAL PHARMACOLOGY Investigations into the mode of action of furosemide have utilized micropuncture studies in rats, stop flow experiments in dogs and various clearance studies in both humans and experimental animals. It has been demonstrated that furosemide inhibits primarily the reabsorption…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.