NDAORALTABLET
Approved
Sep 1994
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
3/8 — Basic
FUROSEMIDE (furosemide) by R-Pharm US is clinical pharmacology investigations into the mode of action of furosemide have utilized micropuncture studies in rats, stop flow experiments in dogs and various clearance studies in both humans and experimental animals. First approved in 1994.
Drug data last refreshed 8h ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Furosemide is a potent loop diuretic that inhibits sodium and chloride reabsorption in the proximal tubule, distal tubule, and loop of Henle, making it highly efficacious for fluid overload management. It is indicated for heart failure, renal impairment, and essential hypertension, with oral tablet formulation offering 60-64% bioavailability and a 2-hour duration of action. The drug works through a unique multi-site renal mechanism independent of carbonic anhydrase or aldosterone inhibition.
LOE Approaching
As loss of exclusivity approaches, the brand team will shift focus to generic transition planning and cost management rather than expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY Investigations into the mode of action of furosemide have utilized micropuncture studies in rats, stop flow experiments in dogs and various clearance studies in both humans and experimental animals. It has been demonstrated that furosemide inhibits primarily the reabsorption…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.