NDAORALTABLET
Approved
Nov 1983
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
FUROSEMIDE (furosemide) by Molecular Devices is clinical pharmacology investigations into the mode of action of furosemide have utilized micropuncture studies in rats, stop flow experiments in dogs, and various clearance studies in both humans and experimental animals. First approved in 1983.
Drug data last refreshed 6h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Furosemide is a loop diuretic that inhibits sodium and chloride absorption in the proximal tubule, distal tubule, and loop of Henle, making it one of the most potent diuretics available. It is used to treat edema associated with congestive heart failure, renal disease, and hepatic cirrhosis, as well as hypertension. The drug has a rapid onset (within 1 hour) and peak effect within 1–2 hours, with a duration of 6–8 hours.
LOE Approaching
As a mature, approaching loss of exclusivity product with high generic competition, roles focus on cost management, generic transition planning, and off-label or combination strategies rather than growth-oriented expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY Investigations into the mode of action of furosemide have utilized micropuncture studies in rats, stop flow experiments in dogs, and various clearance studies in both humans and experimental animals. It has been demonstrated that furosemide inhibits primarily the absorption of…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.