FOSCAVIR

LOE Approaching

foscarnet sodium

NDAINTRAVENOUSSOLUTIONPriority Review

Approved

Sep 1991

Lifecycle

LOE Approaching

Competitive Pressure

30/100

Mechanism of Action

Mechanism of Action Foscarnet exerts its antiviral activity by a selective inhibition at the pyrophosphate binding site on virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases. Foscarnet does not require activation (phosphorylation) by thymidine kinase or…

Indications (2)

CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients

External Resources

DailyMed

Full prescribing information

FDA Drugs@FDA

FDA approval history

RxNorm

Drug nomenclature & identifiers