FOMEPIZOLE (fomepizole) by Gland Pharma is mechanism of action: fomepizole is a competitive inhibitor of alcohol dehydrogenase. First approved in 2023.
Drug data last refreshed 20h ago
Mechanism of Action: Fomepizole is a competitive inhibitor of alcohol dehydrogenase. Alcohol dehydrogenase catalyzes the oxidation of ethanol to acetaldehyde. Alcohol dehydrogenase also catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.…
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Antidote
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose
Specified Drug-use Survey of Fomepizole Intravenous Infusion (All-case Surveillance)
Phase IIa Study of Fomepizole for Acetaldehyde Toxicity After Ethanol Exposure in Subjects With Altered Ethanol Metabolism