FOLIC ACID
LOE ApproachingNDAORALTABLET
Approved
Jun 1947
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
16
Data completeness
3/8 — Basic
FOLIC ACID by Eli Lilly and Company is clinical pharmacology folic acid acts on megaloblastic bone marrow to produce a normoblastic marrow. First approved in 1947.
Drug data last refreshed Yesterday · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Folic acid is an oral small-molecule B-vitamin supplement approved in 1947 for prevention and treatment of folate deficiency. It is indicated across a broad spectrum of conditions including cancer types (colorectal, lung, breast, prostate), rheumatoid arthritis, cardiovascular disease, and critically, prevention of congenital malformations and adverse pregnancy outcomes. The drug works by serving as a coenzyme in one-carbon transfer reactions essential for DNA synthesis, cell division, and normal fetal development.
LOE Approaching
As a legacy product approaching loss of exclusivity with minimal competitive pressure (score: 30), the brand team is likely focused on life-cycle extension and defensive positioning rather than growth expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY Folic acid acts on megaloblastic bone marrow to produce a normoblastic marrow. In man, an exogenous source of folate is required for nucleoprotein synthesis and the maintenance of normal erythropoiesis. Folic acid is the precursor of tetrahydrofolic acid, which is involved as…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.