FLOLAN

LOE Approaching

epoprostenol sodium

NDAINJECTIONINJECTABLEPriority Review
Approved
Sep 1995
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
6

Mechanism of Action

2 major pharmacological actions: (1) direct vasodilation of pulmonary and systemic arterial vascular beds and (2) inhibition of platelet aggregation.

Clinical Trials (5)

NCT02705807Phase 4Completed

Evaluation of a New Thermostable Formulation of FLOLAN in Japanese Subjects

Started May 2016
10 enrolled
Cardiovascular Disease
NCT01462565Phase 4Completed

Study of a New Thermo Stable Formulation of Epoprostenol Sodium to Treat Pulmonary Arterial Hypertension (PAH)

Started Nov 2011
16 enrolled
Hypertension, Pulmonary
NCT00643604Phase 4Terminated

Rapid Switch From Flolan to Remodulin in the Outpatient Clinic

Started Mar 2008
7 enrolled
Hypertension, Pulmonary
NCT00439946Phase 4Terminated

Safety, Efficacy, and Treatment Satisfaction Switching From Flolan to Remodulin Using the Crono Five Ambulatory Pump in Patients With PAH

Started Feb 2007
8 enrolled
Pulmonary Arterial Hypertension
NCT00058929Phase 4Completed

A Transition Study From Flolan® to Remodulin® in Patients With Pulmonary Arterial Hypertension

Started Oct 2002
39 enrolled
Pulmonary Arterial HypertensionPulmonary Hypertension