FLAGYL

LOE Approaching

metronidazole

NDAORALCAPSULE
Approved
May 1995
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20

Mechanism of Action

CLINICAL PHARMACOLOGY Absorption Disposition of metronidazole in the body is similar for both oral and intravenous dosage forms. FLAGYL 375 capsules have been shown to have a rate and extent of absorption similar to metronidazole tablets (FLAGYL) and were bioequivalent at an equal single dose of…

Pharmacologic Class:

Nitroimidazole Antimicrobial

Clinical Trials (5)

NCT03830333Phase 3Completed

Ceftolozane/Tazobactam (MK-7625A) Plus Metronidazole Versus Meropenem for Participants With Complicated Intra-abdominal Infection (MK-7625A-015)

Started Mar 2019
268 enrolled
Complicated Intra-abdominal Infections
NCT03329092Phase 3Completed

A Study to Determine the Efficacy, Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) Versus Meropenem (MER) ± Colistin (COL) for the Treatment of Serious Infections Due to Gram Negative Bacteria.

Started Apr 2018
422 enrolled
Complicated Intra-abdominal InfectionHosptial Acquired PneumoniaVentilator Associated Pneumonia
NCT03217136Phase 2Completed

MK-7625A Plus Metronidazole Versus Meropenem in Pediatric Participants With Complicated Intra-Abdominal Infection (cIAI) (MK-7625A-035)

Started Apr 2018
94 enrolled
Complicated Intra-Abdominal Infection
NCT02911298Phase 1Completed

Pharmaco-Scintigraphic Study to Evaluate the Release Profile of Metronidazole Benzoate Capsules

Started Nov 2016
NCT02739997Phase 3Completed

Study of Ceftolozane/Tazobactam (MK-7625A) in Combination With Metronidazole in Japanese Participants With Complicated Intra-abdominal Infection (MK-7625A-013)

Started Apr 2016
100 enrolled
Intra-abdominal InfectionComplicated Intra-abdominal Infection