NDAVAGINALINSERT, EXTENDED RELEASE
Approved
Mar 2003
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
5/8 — Partial
FEMRING (estradiol acetate) by Millicent Pharma is characteristics. Approved for moderate to severe vasomotor symptoms due to menopause (), moderate to severe vulvar, vaginal atrophy due to menopause () 1. First approved in 2003.
Drug data last refreshed 21m ago · AI intelligence enriched 21m ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
FEMRING is an extended-release vaginal insert containing estradiol acetate, a small-molecule estrogen that treats moderate to severe vasomotor symptoms (hot flushes) and vulvar/vaginal atrophy associated with menopause. The drug works by binding to estrogen receptors in target tissues, reducing elevated gonadotropin levels characteristic of postmenopause and restoring local estrogen activity.
$7MPart D
LOE ApproachingProduct approaching loss of exclusivity with modest Medicare utilization signals consolidation or transition planning for commercial teams.
Mechanism of Action
characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level. The primary source of estrogen in…
Indications (3)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.