NDAVAGINALINSERT, EXTENDED RELEASE
Approved
Mar 2003
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Mechanism of Action
characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level. The primary source of estrogen in…