BLAINJECTIONINJECTABLEPriority Review
Approved
Aug 2023
Lifecycle
Growth
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
7/8 — Comprehensive
Priority Review
EYLEA HD (aflibercept) by Regeneron is vascular endothelial growth factor inhibitors [moa]. Approved for vascular endothelial growth factor inhibitor [epc]. First approved in 2023.
Drug data last refreshed 16h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
EYLEA HD (aflibercept) is a fusion protein and VEGF inhibitor administered via intravitreal injection for retinal diseases. It binds and inactivates vascular endothelial growth factor (VEGF), reducing abnormal blood vessel growth and leakage in the eye. The HD formulation represents an optimized version of the original EYLEA, approved in August 2023.
$0.656MPart D
GrowthEarly-stage growth product with modest Medicare Part D penetration; commercial team expansion expected as awareness and adoption accelerate.
Mechanism of Action
Vascular Endothelial Growth Factor Inhibitors
Pharmacologic Class:
Vascular Endothelial Growth Factor Inhibitor
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Prospective Trial of the Efficacy and Safety of a Personalized Regimen of High-dose Aflibercept 8mg on Treatment-naive Polypoidal Choroidal Vasculopathy: the PALLAS Trial
Started Dec 2026
50 enrolled
Polypoidal Choroidal VasculopathyPolypoidal Choroidal Vasculopathy (PCV)
A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-005)
Started Sep 2026
1,104 enrolled
Diabetic RetinopathyMacular Edema
A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004)
Started Aug 2026
960 enrolled
Diabetic RetinopathyMacular Edema
A Study to Evaluate the Efficacy and Safety of Tabirafusp Tedromer Compared to Aflibercept in Participants With DME - ALTO
Started Aug 2026
910 enrolled
Diabetic Macular Edema (DME)
A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration
Started May 2026
304 enrolled
Neovascular Age-related Macular DegenerationnAMD
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.