EYLEA

Peak

aflibercept

BLAINJECTIONINJECTABLEPriority Review
Approved
Nov 2011
Lifecycle
Peak
Competitive Pressure
30/100
Clinical Trials
39

Mechanism of Action

Vascular Endothelial Growth Factor Inhibitors

Pharmacologic Class:

Vascular Endothelial Growth Factor Inhibitor

Indications (1)

Clinical Trials (5)

NCT07389980Phase 3Recruiting

Prospective Trial of the Efficacy and Safety of a Personalized Regimen of High-dose Aflibercept 8mg on Treatment-naive Polypoidal Choroidal Vasculopathy: the PALLAS Trial

Started Dec 2026
50 enrolled
Polypoidal Choroidal VasculopathyPolypoidal Choroidal Vasculopathy (PCV)
NCT07365371Phase 4Not Yet Recruiting

A Prospective, Multicenter, Open-label, Randomized Clinical Trial to Evaluate the Efficacy, Durability, and Safety of Aflibercept 8mg in Different Treatment Regimens in Chinese Patients With Polypoidal Choroidal Vasculopathy (PCV)

Started Jan 2026
174 enrolled
Polypoidal Choroidal Vasculopathy (PCV)Neovascular Age Related Macular Degeneration (AMD)
NCT07129239Phase 3Not Yet Recruiting

High Dose (HD) Aflibercept Switch in Neovascular Age-related Macular Degeneration (nAMD): to Load or Maintain (HEIRLOOM)

Started Aug 2025
180 enrolled
Wet Age-related Macular Degeneration (wAMD)
NCT07105228N/ACompleted

Incidence of Retinal Vasculitis Among Patients Receiving Aflibercept: A US Real-World Evidence Study

Started Jul 2025
290,000 enrolled
Retinal Vasculitis
NCT06662994Phase 4Recruiting

High Dose Aflibercept in Diabetic Macular Edema in Patients With Previous Vitrectomy

Started Jul 2025
15 enrolled
Diabetic Macular Edema (DME)