ESIDRIX

LOE Approaching

hydrochlorothiazide

NDAORALTABLET
Approved
Feb 1959
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20

Mechanism of Action

Mechanism of Action Lisinopril inhibits angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the…

Indications (1)

Clinical Trials (5)

NCT06205407Phase 1Completed

A Study to Learn How the Body Processes Spironolactone and Hydrochlorothiazide Film Coated Tablets Manufactured at Two Sites: Viatris and Neolpharma

Started Dec 2023
42 enrolled
Healthy Participants
NCT03205137N/AWithdrawn

Comparison of the Medication Adherence of Patients Treated With Telmisartan/Hydrochlorothiazide or Telmisartan/Amlodipine Fixed Dose Combination (FDC) Versus Double-pill Combination Therapy in Real-world Japanese Therapeutic Practice

Started Jun 2022
0
Hypertension
NCT03640221Phase 4Withdrawn

Ertugliflozin Versus Hydrochlorothiazide in Reducing Sympathetic Neural Overactivity in Patients With Hypertension and Recently-diagnosed Type 2 Diabetes.

Started Sep 2018
0
HypertensionDiabetes Mellitus, Type 2
NCT03387657Phase 1Completed

A Drug to Drug Interaction Study of Sotagliflozin With Hydrochlorothiazide

Started Jan 2018
16 enrolled
Type 2 Diabetes Mellitus
NCT03031496Phase 1Completed

Bioequivalence Study Between GSK3542503 Hydrochlorothiazide + Amiloride Hydrochloride 50 mg: 5 mg Tablets and Reference Product in Healthy Adult Participants Under Fasting Conditions

Started Mar 2017
42 enrolled
Hypertension