ENLON-PLUS
LOE Approachingatropine sulfate; edrophonium chloride
NDAINJECTIONINJECTABLE
Approved
Nov 1991
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
ENLON-PLUS (atropine sulfate; edrophonium chloride) is muscarine-like actions of acetyl-choline and is therefore classified as an antimuscarinic agent. Approved for older for: atropine is an anticholinergic agent indicated in adults, older for: cycloplegia () mydriasis () penalization of the healthy eye in the treatment of amblyopia () 1. First approved in 1991.
Drug data last refreshed 6d ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ENLON-PLUS is a fixed-dose combination injectable containing atropine sulfate (anticholinergic) and edrophonium chloride (cholinesterase inhibitor) approved in 1991. It is indicated for cycloplegia, mydriasis, and penalization of the healthy eye in amblyopia treatment. The atropine component blocks muscarinic receptors to prevent pupillary constriction and ciliary muscle contraction, while edrophonium enhances acetylcholine availability.
LOE Approaching
Product is nearing loss of exclusivity with moderate competitive pressure (30), signaling potential team contraction or redeployment of commercial talent.
Mechanism of Action
muscarine-like actions of acetyl-choline and is therefore classified as an antimuscarinic agent. Atropine is relatively selective for muscarinic receptors. Its potency at nicotinic receptors is much lower, and actions at non-muscarinic receptors are generally undetectable clinically. Atropine does…
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
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