NDAINJECTIONINJECTABLE
Approved
Nov 1991
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
ENLON-PLUS (atropine sulfate; edrophonium chloride) by Pharmobedient is muscarine-like actions of acetyl-choline and is therefore classified as an antimuscarinic agent. Approved for older for: atropine is an anticholinergic agent indicated in adults, older for: cycloplegia () mydriasis () penalization of the healthy eye in the treatment of amblyopia () 1. First approved in 1991.
Drug data last refreshed 13h ago · AI intelligence enriched Yesterday
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ENLON-PLUS is a fixed-dose combination injectable containing atropine sulfate (an anticholinergic agent) and edrophonium chloride (a cholinesterase inhibitor). It is indicated for cycloplegia, mydriasis, and penalization of the healthy eye in amblyopia treatment. The drug works by blocking muscarinic cholinergic receptors, preventing acetylcholine's effects and causing pupil dilation and loss of accommodation.
LOE Approaching
Product approaching loss of exclusivity with minimal commercial momentum; brand team likely focused on transition planning and cost management rather than growth initiatives.
Mechanism of Action
muscarine-like actions of acetyl-choline and is therefore classified as an antimuscarinic agent. Atropine is relatively selective for muscarinic receptors. Its potency at nicotinic receptors is much lower, and actions at non-muscarinic receptors are generally undetectable clinically. Atropine does…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.