NDAVAGINALINSERT
Approved
Jun 2007
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
5/8 — Partial
ENDOMETRIN (progesterone) by Ferring Pharmaceuticals. Approved for progesterone [epc]. First approved in 2007.
Drug data last refreshed 5h ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ENDOMETRIN (progesterone) is a vaginal insert containing micronized progesterone, a naturally occurring hormone used to support the luteal phase in assisted reproductive technology (ART) cycles. It is indicated for progesterone supplementation in women undergoing fertility treatment. The drug works by providing exogenous progesterone to prepare and maintain the endometrium for embryo implantation.
$0.008BPart D
LOE ApproachingProduct approaching loss of exclusivity with minimal recent Medicare claims, suggesting a niche, declining market presence and likely reduced commercial team investment.
Mechanism of Action
Pharmacologic Class:
Progesterone
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Individualized Prolonged Luteal Support After Fresh Embryo Transfer in Women With Low Progesterone
Started Mar 2027
214 enrolled
PregnancyProgesterone SupplementationLow Serum Progesterone
Cycle-to-cycle Variability of Progesterone in the Endometrium in Patients Undergoing an Euploid Blastocyst Transfer in a Hormone Replacement Therapy (HRT) Cycle (PROMICOFET)
Started Oct 2026
70 enrolled
FertilityImplantation, Embryo
Comparing the Pharmacokinetics of a Progesterone Ring Versus a Progesterone Vaginal Insert
Started Sep 2026
60 enrolled
Pre Term Birth
Exogenous Progesterone as Ovulation Trigger
Started Jul 2026
10 enrolled
OvulationOvarian FunctionAssisted Reproductive Treatments+2 more
Comparison of Two Vaginal Progesterone Forms in Frozen Embryo Transfer
Started Nov 2024
400 enrolled
Frozen Embryo Transfer (FET)InfertilityArtificial Cycle+1 more
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.