NDAORALTABLETPriority Review
Approved
Feb 2019
Lifecycle
Peak
Competitive Pressure
30/100
Clinical Trials
3
Data completeness
5/8 — Partial
Priority Review
EGATEN (triclabendazole) by Novartis is cytochrome p450 2c19 inhibitors [moa]. Approved for anthelmintic [epc]. First approved in 2019.
Drug data last refreshed 9h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
EGATEN (triclabendazole) is an oral small-molecule anthelmintic approved by the FDA in February 2019 for the treatment of fascioliasis, a parasitic trematode infection caused by Fasciola hepatica and Fasciola gigantica. The drug works as a cytochrome P450 2C19 inhibitor to eliminate the infection.
PeakPost-LOE
EGATEN is in peak commercial phase as a Novartis specialty product; team size and investment levels are likely moderate given the niche indication and geographic concentration in endemic regions.
Mechanism of Action
Cytochrome P450 2C19 Inhibitors
Pharmacologic Class:
Anthelmintic
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (3)
One and Two Doses of Oxfendazole Versus a Schedule of Two Doses of Triclabendazole in Chronic Fascioliasis
Started Aug 2026
336 enrolled
Fascioliasis
Study of Safety, Tolerability and Clinical Outcomes of Egaten in Fascioliasis Patients (6 Years of Age or Older).
Started Feb 2022
301 enrolled
Fascioliasis
Compassionate Use of Triclabendazole for the Treatment of Parasites (Prior to FDA Approval; Expanded Access Program)
Parasitic Disease
Career Relevance
Working on EGATEN offers exposure to specialty pharmaceuticals and rare disease management within a Novartis portfolio, with strong potential for developing expertise in anthelmintic and tropical disease markets. The imminent LOE creates a dynamic environment for professionals focused on commercial strategy, market defense, and lifecycle optimization.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.