NDATOPICALSPONGE
Approved
Jul 1989
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
6
Data completeness
3/8 — Basic
E-Z PREP (povidone-iodine) by Bayer is clinical pharmacology: a placebo-controlled study in 38 normal volunteers yielded data for 36 subjects who showed a mean log10 reduction of 3. First approved in 1989.
Drug data last refreshed 11h ago · AI intelligence enriched 14h ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
E-Z PREP is a topical povidone-iodine 5% sterile ophthalmic prep solution used for preoperative skin antisepsis, particularly in ophthalmologic procedures. It works through iodine's broad-spectrum antimicrobial mechanism, achieving a mean 3.05 log10 reduction in aerobic bacteria within 10 minutes of application. The product is supplied as a pre-saturated sponge for convenient clinical use.
LOE Approaching
Product nearing loss of exclusivity with moderate competitive pressure (30%), likely a mature/declining team focused on margin protection and generic transition planning.
Mechanism of Action
CLINICAL PHARMACOLOGY: A placebo-controlled study in 38 normal volunteers yielded data for 36 subjects who showed a mean log10 reduction of 3.05 log10 units in total aerobes at 10 minutes following prepping the skin with BETADINE* 5% Sterile Ophthalmic Prep Solution compared with reduction of 1.58…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (6)
SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder Arthroplasty
Started Jun 2023
60 enrolled
SurgerySurgical Site InfectionCutibacterium Acnes+1 more
Treatment of Adenoviral Conjunctivitis With SHP640 Compared to Povidone-iodine (PVP-I) and Placebo
Started Mar 2017
219 enrolled
Adenoviral Conjunctivitis
Prevention of Surgical Site Infections: Effectiveness of Nasal Povidone-Iodine and Nasal Mupirocin
Started Mar 2011
1,874 enrolled
Surgical Site Infection
Povidone-iodine Antisepsis for Strabismus Surgery
Started Sep 2009
70 enrolled
StrabismusSurgeryEndophthalmitis
A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine
Started Mar 2008
78 enrolled
Fungal Keratitis
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.