DYRENIUM

LOE Approaching

triamterene

NDAORALCAPSULEPriority Review
Approved
Aug 1964
Lifecycle
LOE Approaching
Competitive Pressure
30/100

Mechanism of Action

CLINICAL PHARMACOLOGY Triamterene has a unique mode of action; it inhibits the reabsorption of sodium ions in exchange for potassium and hydrogen ions at that segment of the distal tubule under the control of adrenal mineralocorticoids (especially aldosterone). This activity is not directly related…

Pharmacologic Class:

Potassium-sparing Diuretic

Indications (8)

the treatment of edema associated with congestive heart failurecirrhosis of the liverthe nephrotic syndromepregnancy (howeverjustheart failuredevelopment of toxemia of pregnancythere is no satisfactory evidence
External Resources
DailyMed
Full prescribing information
FDA Drugs@FDA
FDA approval history
RxNorm
Drug nomenclature & identifiers