NDATOPICALSOLUTION
Approved
Dec 1985
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
DYNA-HEX 2 (chlorhexidine gluconate) by Johnson & Johnson is clinical pharmacology periogard® (chlorhexidine gluconate oral rinse usp, 0. First approved in 1985.
Drug data last refreshed 4h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DYNA-HEX 2 is a chlorhexidine gluconate 0.12% oral rinse solution approved by the FDA for antimicrobial activity in the oral cavity. It works by reducing bacterial counts (54-97%) in dental plaque through broad-spectrum antimicrobial action on aerobic and anaerobic organisms. Approximately 30% of the active ingredient is retained in the oral cavity after rinsing and slowly released into oral fluids.
LOE Approaching
Product is in late-stage lifecycle with approaching loss of exclusivity; commercial teams are likely focused on generic transition planning and lifecycle extension strategies.
Mechanism of Action
CLINICAL PHARMACOLOGY PerioGard® (Chlorhexidine Gluconate Oral Rinse USP, 0.12%) provides antimicrobial activity during oral rinsing. The clinical significance of chlorhexidine gluconate oral rinse's antimicrobial activities is not clear. Microbiological sampling of plaque has shown a general…
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.