DUODOTE

LOE Approaching

atropine and pralidoxime chloride

NDAINTRAMUSCULARINJECTABLEPriority Review
Approved
Sep 2006
Lifecycle
LOE Approaching
Competitive Pressure
30/100

Mechanism of Action

acetylcholine, including excess acetylcholine due to organophosphorus poisoning, at muscarinic cholinergic receptors on smooth muscle, cardiac muscle, secretory gland cells, and in peripheral autonomic ganglia and the central nervous system. Pralidoxime Pralidoxime reactivates acetylcholinesterase…