NDAINTRAMUSCULARINJECTABLEPriority Review
Approved
Sep 2006
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
Priority Review
DUODOTE (atropine and pralidoxime chloride) by Medcaptain Medical Technology is acetylcholine, including excess acetylcholine due to organophosphorus poisoning, at muscarinic cholinergic receptors on smooth muscle, cardiac muscle, secretory gland cells, and in peripheral autonomic ganglia and the central nervous system. Approved for poisoning by organophosphorus nerve agents. First approved in 2006.
Drug data last refreshed 33m ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DUODOTE is a fixed-dose combination of atropine and pralidoxime chloride administered intramuscularly for treatment of organophosphorus nerve agent or insecticide poisoning. Atropine blocks excess acetylcholine at muscarinic receptors while pralidoxime reactivates inhibited acetylcholinesterase, restoring cholinergic function. This dual mechanism addresses both the immediate symptoms and underlying biochemical damage of organophosphorus exposure.
LOE Approaching
DUODOTE operates in a specialized, limited-volume market with approximately 30% competitive pressure; team size and growth opportunities are likely constrained by niche indication.
Mechanism of Action
acetylcholine, including excess acetylcholine due to organophosphorus poisoning, at muscarinic cholinergic receptors on smooth muscle, cardiac muscle, secretory gland cells, and in peripheral autonomic ganglia and the central nervous system. Pralidoxime Pralidoxime reactivates acetylcholinesterase…
Indications (1)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.